Product interactions for this drug/drug-class include:

• Tenapanor with Laxatives; Stool Softeners (Severe Interaction)
• Trofinetide with Laxatives (Severe Interaction)
• Selected Bowel Preparations with Stimulant Laxatives (Severe Interaction)

Before taking this medication, tell your doctor if you've had:

• Appendicitis or symptoms of appendicitis (such as nausea/vomiting, sudden or unexplained stomach/abdominal pain)
• A sudden change in bowel habits that lasts for longer than 2 weeks
• Bleeding from the rectum
• Intestinal blockage