D-ribose shows promise in the treatment of fibromyalgia and myalgic encephalomyelitis, better known as chronic fatigue syndrome. A 2017 review of dietary modifications for chronic fatigue patients reports that D-ribose supplementation significantly improved energy levels and overall mood.

D-Ribose levels decline during the low oxygen states which may be present in ME/CFS and FM. When those conditions are present, cells turn to bringing two ADP molecules together to form ATP. The AMP left over is washed out – leaving the cell depleted in purines. Bob Naviaux found reduced purines in ME/CFS. D-Ribose is able to enhance purine levels.

D-ribose helps your cells to clear out the lactic acid and rebuild their energy stores. Over time, this will help to increase your energy levels. (3) Dosing: Those with chronic fatigue syndrome will need to add a d-ribose supplement. I recommend starting with 3-5 grams of d-ribose each day.