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'I Was Diagnosed With a Rare Genetic Condition At 20—These Are the First Symptoms I Noticed'
Affecting one in 36,000 people, von Hippel-Lindau (VHL) is caused by a mutation in the VHL gene and causes tumors to grow in certain parts of the body, including the brain, spinal cord ...
Nature4y
Environmental Cues Like Hypoxia Can Trigger Gene Expression and Cancer Development
While some control of gene expression is mediated through ... for binding with another cellular protein called the von Hippel-Lindau tumor suppressor (pVHL). The pVHL is a protein involved in ...
University of Sheffield3y
Dr Freek van Eeden
In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish. The zebrafish provides a powerful organism to ...
Nature4mon
Sunitinib versus interferon-α in metastatic RCC
Approximately three-quarters of renal cancers are clear-cell carcinomas, and most tumors of this histologic subtype have inactivating mutations of the von Hippel–Lindau gene. This inactivation ...
Medscape28d
Pheochromocytoma: Recommendations for Clinical Practice from the First International Symposium
Clinical manifestations in the patient or other family members might also signal a particular disease-causing gene (e.g. a VHL gene mutation suggested by findings of subtle retinal vascular lesions).