We tested their functional importance by deletion analysis in reporter assays. We also identified candidate transcription factor binding sites within the VHL promoter and investigated the functional ...

sund.ku.dk Background Historically, the survival of patients with von Hippel-Lindau disease (vHL) has been poorer than that of the general population. We aimed to determine whether the survival of VHL ...

Background: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome. Currently, studies on tyrosine kinase inhibitor (TKI) therapy for VHL disease are scarce. In this study ...

In early December, Welireg was quietly listed on the PBS. Well quiet for most, but it’s also life-altering for about 300 Australians who live with the genetic condition VHL or von Hippel-Lindau ...

In bilateral RCC, should there be a retroperitoneal mass, PG should be strongly considered and ruled out in addition to the evaluation of Von Hippel-Lindau syndrome. Contributors Study design: FMP and ...

Objective: In this study, our aim was to search for new genotype-phenotype correlations in patients with Von Hippel-Lindau (VHL) disease. This study was approved by the Ethics Committee of the Clinics ...

NEW YORK – The European Commission (EC) on Tuesday granted conditional marketing authorization to Merck's HIF-2α inhibitor Welireg (belzutifan) for some von Hippel-Lindau (VHL) disease-associated ...

The European Commission (EC) has conditionally approved MSD's Welireg, an oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor, as a single agent for the treatment of adults with von Hippel-Lindau ...

Cabozantinib in patients (pts) with non-locally pretreated brain metastases (BM) from renal cell carcinoma (RCC): Results of the multicenter CABRAMET phase II trial (NCT03967522). Evaluating the ...

Rad Tingle, kitchen manager at Ribble Court Care Home in Much Hoole, Preston, part of Sandstone Care, is set to take on a ...