They typically involve nucleotide changes that alter the amino acid sequence of the VHL protein, rendering it dysfunctional, although sometimes the relevant gene is deleted entirely. The mutations ...

Here we demonstrate a critical role for the von Hippel-Lindau (VHL) tumour suppressor gene product pVHL in HIF-1 regulation. In VHL-defective cells, HIF alpha-subunits are constitutively ...

A growing number of proteins have been shown to be susceptible to ligand-induced protein degradation within cells. Most of these outcomes are mediated by two E3 ligases: CRBN and VHL. To fully ...