Medically reviewed by Erika Prouty, PharmD Acetaminophen, including the brand Tylenol, is the most frequently used drug in the world. It is an effective pain reducer and considered generally safe, but ...

On the other hand, some common side effects you might experience with ibuprofen, but not with acetaminophen include: Heartburn Stomach ache Indigestion Diarrhea In rare cases, ibuprofen might also ...