The site and mechanism for the analgesic effect of acetaminophen has not been determined but is thought to primarily involve central actions. Caffeine is a methylxanthine and CNS stimulant.
Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets. Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma ...
The researchers found that caffeine triples the amount of a toxic by-product, N-acetyl-p-benzoquinone imine (NAPQI), which the enzyme produces while breaking down acetaminophen.
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