The site and mechanism for the analgesic effect of acetaminophen has not been determined but is thought to primarily involve central actions. Caffeine is a methylxanthine and CNS stimulant.

The researchers found that caffeine triples the amount of a toxic by-product, N-acetyl-p-benzoquinone imine (NAPQI), which the enzyme produces while breaking down acetaminophen.

In the meantime, over-the-counter pain relievers such as Motrin, Aleve, Advil, and Tylenol can help to alleviate these headaches. 2. Nausea Some people experience flu-like symptoms with caffeine ...

“Tylenol is safe to use during all three trimesters,” explains ... says Dr. Silver. As for headaches? “Caffeine works really well,” she says. “Just a little dose of coffee [can solve] the problem.” ...

The three ingredients in an OTC migraine cocktail, or combination medication, include acetaminophen, aspirin, and caffeine. The three ingredients in an OTC migraine cocktail, or combination ...