Conceptually, the body’s fibrinolytic mechanism can get bumped into overdrive by things like trauma, resulting in coagulopathy. The use of TXA has been hypothesized to help reduce the incidence ...

Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking lysine-binding sites on plasminogen, which contribute to reduced bleeding, ...

Objective To understand more about the individual variation in the time course of fibrinolysis following major injury and to assess the potential for stratification of trauma patients for tranexamic ...

There are around 5,400 deaths each year from injuries in the UK, of which 2,400 occur before hospital arrival. Tranexamic acid (TXA) has been shown to reduce mortality from bleeding in trauma. Early ...