By employing a proprietary linker and conjugation chemistry, we developed an ADC with a TLR7 agonist covalently linked to a mouse IgG2a antibody that targets mouse tyrosinase-related protein 1 (TRP1 ...

newcastle.edu.au Background Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some ...

Here we used R848, a TLR7/8 agonist, and demonstrate that only persistent TLR7 stimulation at an epithelial barrier such as the skin or gut was able to drive a unique CCR2-independent BM emergency ...

Moreover, it is important to know if these suppressive effects of IRAK4 elimination on TLR7-dependent lupus-traits are due to the loss of susceptibility loci resulting from the introduction of ...

The expression of TLRs on RPE was determined, and both aEAU and tEAU mice exhibited induced tlr7 expression. The TLR7 agonist R848 was shown to induce aggressive disease progression, along with ...

The TLR7 agonist imiquimod has been approved for the treatment of genital warts caused by HPV. TLR3 and TLR7–9 agonists showed promising results for the treatment of viral infections ...

Eikon’s lead candidate EIK1001 is being investigated for melanoma in combination with MSD’s Keytruda in a Phase III trial.

Its lead candidate, MBS8, consists of a small-molecule agonist of Toll-like receptor 7 (TLR7) in-licensed from the University of California San Diego, USA, and formulated by MonTa in collaboration ...

Its lead program, CAN1012, is a novel, long-acting selective Toll-like receptor 7 (TLR7) agonist with best-in-class potential. CAN1012 has several key differentiating properties, including highly ...

Methods: Human primary dendritic cells and whole blood were stimulated with gardiquimod (TLR7 agonist) to evaluate the effect of R835 on Interferon-alpha (IFN-α) production. R835 was further evaluated ...