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Several observations from preclinical and short-term clinical studies support a role for sildenafil in the ... fraction (most with associated pulmonary hypertension) followed for relatively ...

Expert Rev Resp Med. 2009;3(2):187-196. Lung transplantation (LT) is typically offered as a last resort to patients with PAH who fail to respond to medical therapy. Although CTD is not an absolute ...

Effects of the combination of bosentan and sildenafil versus sildenafil monotherapy on pulmonary arterial hypertension (PAH) (Compass-2). ClinicalTrials.gov. Updated February 4, 2025. Accessed ...

In treatment-naïve patients with PAH, initial monotherapy improves exercise capacity, hemodynamics, and outcomes when compared with those noted among untreated patients. In patients who are newly ...

Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil.