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Spider-Man: No Way Home ending explained: Multiverse of madness
This caused a break in the multiverse, bringing in anyone who ... experiences (Peter-3's loss of Gwen Stacy in The Amazing Spider-Man 2 and both of their losses of their own Uncle Bens) to bond ...
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Where Is Your Friendly Neighborhood Spider-Man Set in the Marvel Multiverse?
Your Friendly Neighborhood Spider-Man does not take place in the MCU timeline. It takes place in an alternate universe adjacent to the MCU, within the multiverse. The MCU takes place on Earth-616.