Background: Acute rheumatic fever (ARF) and its sequelae, chronic rheumatic heart disease, remain important causes of morbidity and mortality worldwide, but there is little recent information ...

This review of the medical literature reveals that the incidence of rheumatic fever has been declining for at least 150 years, preceding by many decades the use of penicillin as a preventive measure.

Their use in the periodic fever syndromes has enabled the control ... of the various biologics used to treat a number of childhood rheumatic diseases, with particular emphasis on juvenile ...