Additional studies in collaboration with Ibañez-Tallon showed that lynx-1 altered the function of nicotinic acetylcholine receptors. Acetylcholine is a neurotransmitter that helps to activate muscles ...

Mr. Big is located in a gene called CHRNA5F (nicotinic acetylcholine receptor 5) and influences how well nicotine binds to receptors in the brain. People with a certain version of Mr. Big ...

“To have a drug that works as well [as opioids] but is actually targeting a completely independent receptor system is really one of those holy grails of the drug industry,” says Daniel McGehee, who ...

Nicotine, a major component of tobacco smoke, could exert either nonreceptor-mediated biological effects or, more importantly, act on the different subtypes of nicotinic brain receptors ...

including a few that code for nicotinic acetylcholine receptors. These receptors bind to nicotine and nicotine derivatives and are found on cells in the nervous system, in the lungs, and elsewhere ...

To understand at the molecular level how genetic variability, particularly with respect to nicotinic receptor genes, influences risk for drug dependence and co-morbid psychiatric disorders. Current ...

Némethy Z The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference ...