Some scenarios dictate using one versus the other. Here are a few examples: Though minocycline and doxycycline can cause any of these, there are some nuances to their side effect profiles.

A low-dose (40 mg) modified formulation of minocycline hydrochloride (DFD-29) was better tolerated and more effective than doxycycline and placebo in patients with moderate to severe ...

the two trials showed significantly greater mean reductions in inflammatory lesion counts with minocycline hydrochloride ...

A study found that DFD-29 was more effective than both doxycycline and placebo, with a favorable risk-benefit profile for ...