The precise mechanism of action of metronidazole is unclear. Infuse over 1hr. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6hrs for 7–10 days; max 4g/24hrs. Bone/joint ...
Severe hepatic impairment (Child-Pugh C): reduce metronidazole dose by 50%. No dose adjustment needed for mild to moderate hepatic impairment, but monitor for metronidazole associated adverse events.
Oral metronidazole and vancomycin have been compared ... Comparisons have been made between vancomycin dosage strengths and relative efficacies. Forty-six hospitalized patients with underlying ...
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