Since metformin isn't approved for weight management, there's no recommended starting dose for weight loss. However, Dr.

Table 1. Ambulatory systolic and diastolic blood pressures before treatment (at the end of the placebo run-in period) and after treatment with either metformin (1500 mg/day) or placebo ...

Take metformin with meals, as this may help reduce side effects. You can divide larger doses, those over 2,000 mg per day, ...

and metformin (either 1,000 mg or 2,000 mg), metformin monotherapy (1,000 mg or 2,000 mg), sitagliptin monotherapy (100 mg), or placebo. Patients with more-severe hyperglycemia who did not meet ...

effectiveness and tolerability while not exceeding the maximum recommended daily dose of sitagliptin 100 mg and metformin 2000 mg. Janumet should generally be administered twice daily with meals ...