More information: Vittoria Borgonetti et al, Excessive alcohol intake produces persistent mechanical allodynia and ...

Allodynia may be due to a peripheral mechanism, reflecting an abnormal reduction of the mechanical threshold in sensitised nociceptors, or to a central mechanism, reflecting the sensitization of ...

Allodynia is a rare type of nerve pain that is triggered by something that wouldn't normally cause pain, such as the touch of your bedsheets, the seam of a sock, or the warmth coming off of ...

Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

This previously unknown family of endogenous TRPV1 ligands and their related linoleic acid metabolites were potent activators of TRPV1 and could initiate the development of mechanical allodynia.

HT-6184 is under development for the treatment of thermal hyperalgesia and mechanical allodynia, Alzheimer’s disease, myelodysplastic syndrome (MDS), chronic inflammation, acute myeloid leukemia (AML) ...