This includes congenital leptin deficiency, a condition that causes mutations in the leptin gene. People with these ...

In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

Though a complex interplay of genes, diet, and environment contribute, 90% of cases share one thing in common: leptin resistance. In lean individuals, fat cells produce the hormone leptin ...