Comparative effectiveness evidence demonstrated that combining a triptan (sumatriptan) and an NSAID (naproxen) had the greatest net benefit, with a larger net benefit than with a triptan ...

For those ages 6 to 12, they recommend ibuprofen and acetaminophen. As for older adults, the safety of nasal sumatriptan ...

It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data have accumulated on the combination of sumatriptan and naproxen sodium, including elucidation ...