Once-daily administration of losartan is possible because the drug's effects are extended by ... such as those taking large doses of a diuretic, the starting dosage should be reduced to 25 mg ...

investigated the combined effects of a low-sodium diet and the diuretic hydrochlorothiazide on proteinuria and blood pressure in Dutch patients receiving the angiotensin-receptor blocker losartan.

Data from the recently published Losartan ... drug combinations that act synergistically rather than with monotherapy, and a combination of a RAAS-inhibiting agent with a long-acting diuretic ...