Both brands contain the same active ingredients: acetaminophen, aspirin, and caffeine. However, they are marketed to serve different purposes. Excedrin Migraine is meant to relieve pain associated ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets. Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma ...

aspirin, and caffeine (Excedrin Extra Strength, Excedrin Migraine, and generics). If your migraines are moderate to severe in pain intensity, and/or disrupt your life, you might benefit from a ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; caplets. May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed ...