Both brands contain the same active ingredients: acetaminophen, aspirin, and caffeine. However, they are marketed to serve different purposes. Excedrin Migraine is meant to relieve pain associated ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets. Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma ...

For plain old headaches, NSAIDs or regular Excedrin (with its extra dose of caffeine) should do the trick. Afrin wins because it's a nasal decongestant spray, and its active ingredients work fast ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; caplets. May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed ...