You can! Simply substitute a box of gluten free cake mix for a delicious gluten free option. Most canned pumpkin is gluten free (though you may want to check the can to be sure).

Pumpkin muffins made with cake mix combine canned pumpkin puree ... Pumpkin pie spice Gluten-free - For a gluten-free muffin, use a gluten-free cake mix. Chocolate pumpkin muffins - For an ...