bolus Folinic acid rescue 15 mg orally every 12 h for four doses (starting 24 h after commencing the methotrexate infusion) For patients with brain metastases the methotrexate dose is increased to ...

This is a milestone study that shows that high-dose MTX toxicity can be avoided after the use of glucarpidase, which does not pass the blood-brain barrier, when it is given with adequate folinic acid.

If you are given too much (overdose) If you are given too much folinic acid, you may experience some of the effects listed under "Side Effects" below. Your doctor has information on how to ...