Headache is the most common side effect in people taking a large dose of fluconazole. In clinical studies, 13% of people taking 150 milligrams (mg) of fluconazole reported experiencing a headache.

Peak fluconazole concentrations of 16–32 µg/ml were reached in all patients. Mean concentrations above 16 µg/ml were maintained for 17.0 ± 8.0 h at an ultrafiltration rate of 1,000 ml/h, ...