To be included in our analysis, a trial had to be an RCT, and to focus on the comparison of the effectiveness and/or toxicity between a first-line antibiotic and a second-line (advanced ...

Despite major changes in the prevalence of antibiotic resistance, the 2011 IDSA guideline for uncomplicated UTI still accurately reflects the efficacy and safety of first-line treatments.

Under the BioVersys and GSK collaboration agreement, GSK is evaluating the early bactericidal activity (EBA) of alpibectir-ethionamide (AlpE) in a pulmonary tuberculosis (TB) trial, in combination ...

Antibiotics are the first line of treatment for most UTIs. Doctors usually prescribe an antibiotic without performing a urine culture first. This is because most UTIs result from an E. coli infection.

For people with Crohn’s, antibiotics may help lower the amount and change the composition of bacteria in the intestines, which may relieve symptoms. They can also treat infections. Antibiotics ...

Results: Twelve RCTs were included in the metaanalysis. First-line antibiotics were associated with lower treatment success compared to second-line antibiotics in the clinically evaluable patients ...