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May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be ...

Compared with placebo, sildenafil improved 6MWD, mPAP, and WHO functional class, all in a dose-dependent fashion. However, incidence of clinical worsening did not differ with sildenafil therapy.