The C-terminal part of A2 extends through the central pore of the B pentamer, and is linked noncovalently to the B-subunits. Intracellularly active toxins can target molecules that have a pivotal ...

Clostridioides difficile (C. difficile) infection (CDI) is a significant healthcare-associated infection, known for its high morbidity and mortality rates, especially in vulnerable populations. CDI ...

Clostridioides difficile infection is a major healthcare-associated infection, causing significant morbidity and mortality, ...

FZ002 is a first-in-class multi-benefit C. difficile treatment, offering ­­­­potent and broad-spectrum neutralization of both toxins A & B, targeted GI delivery, and probiotic activity without ...

Clostridium difficile infection (CDI ... with positive samples then confirmed using a toxin(s) test, to distinguish toxinogenic from nontoxinogenic CDI. Although metronidazole and vancomycin ...

Hypoxia-inducible factor (HIF) signaling protects the intestinal mucosa from injury induced by Clostridium difficile toxins, according to the results of a study published in Gastroenterology.