Once remission has been achieved, however, there is no evidence that steroid enemas will maintain the remission. [27] Thus with the risk of cumulative systemic absorption of topically administered ...

It is one of the reasons to explain the limited use of butyrate enemas in IBD. However, butyrate has a wide variety of effects on the intestinal mucosa, and therefore other factors are likely to ...

Rectally administered topical agents have demonstrated efficacy in the maintenance of distal colitis (DC ... These agents included butyrate, cyclosporine, and nicotine enemas, as well as ...