Maintenance phase: use buprenorphine/naloxone sublingual films at the same buprenorphine dose as Day 2; if intolerant to naloxone, may adjust buprenorphine by 2mg or 4mg increments/decrements to ...

The authors also performed patch tests with buprenorphine TTS in 28 healthy ... followed by a 12-week open-label dose-titration period. Safety was evaluated in all patients. Skin reactions at ...

So, they started giving patients small doses of the drug over a series of days to slowly build up the drug in their systems until their bodies could handle a higher dose of buprenorphine.