For instance, adverse effects of Anusol HC (hydrocortisone acetate) rectal suppositories may include burning, itching, and dryness while Terazol vaginal suppositories can cause headache ...

The pharmacokinetics of promethazine administered in oral syrup and rectal suppositories were highly variable, but, in general, the suppositories produced a lower C max and later t max than the syrup.