Chandrasekaran, MD Taking Tylenol (acetaminophen) together with anti-inflammatory drugs like Aleve (naproxen) or Advil (ibuprofen) is generally considered safe, as long as you don't exceed ...

Naproxen sodium 220mg, diphenhydramine HCl 25mg; caplets. Avoid concomitant other pain relievers. Naproxen may decrease effects of aspirin. Increased risk of GI bleed with anticoagulants ...

Nearly every arthritis sufferer has taken a traditional painkiller like aspirin or Aleve. They are a great solution for relieving pain and inflammation, but there's a definite downside.