It is generally considered safe to take Tylenol together with Aleve or another NSAID. These two medications belong to different drug classes, which means they work in different ways inside your body.

Naproxen sodium 220mg, diphenhydramine HCl 25mg; caplets. Avoid concomitant other pain relievers. Naproxen may decrease effects of aspirin. Increased risk of GI bleed with anticoagulants ...

Naproxen sodium 220mg, pseudoephedrine HCl 120mg; ext-rel tabs; contains sodium 22mg/caplet. Hypertensive crisis with MAOIs (see Contraindications). β-blockers may increase pressor effects of ...