These are not interchangeable and although one could assume the 4-pin 12V would be the better pick, it's actually the 3-pin 5V header that is slightly more advanced with addressable RGB lighting ...

This is it. [Ytai Ben-Tsvi] created an individually addressable RGB LED called the Pixie that is perfect for all the times when you need something bright, colorful, and want to blind a few people ...

12 addressable RGB LEDs and 8 touch sensors. There are also two expansion headers with GPIOs, I2S, I2C, analog audio and USB 2.0 and an onboard microSD card slot. The latter is especially useful ...