The site and mechanism for the analgesic effect of acetaminophen has not been determined but is thought to primarily involve central actions. Caffeine is a methylxanthine and CNS stimulant.

Acetaminophen 250 mg, Aspirin (NSAID) 250 mg and Caffeine 65 mg tablets on behalf of AuroHealth due to mislabeling concerns, ...

When a headache strikes, the last thing you want to do is spend time in the drug store contemplating ... three active ingredients: acetaminophen, aspirin, and caffeine. These ingredients work ...

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets. Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma ...